Labels:text | screenshot | black | black and white | font | document OCR: thin a few The effect of ACTH is rapid, occurring o the minutes. The release of ACTH, leading secretion of cortisol and androgen, occu hour cycle episodically throughout the twenty-four irs in sol (as in in a circadian pattern. ACTH release oco response to low circulating levels of cor Addison's disease) and is inhibited by h circulating levels of cortisol or synthetic py). This glucocorticoids (as in corticosteroid ther othalamic negative feedback probably occurs at hy ir and pituitary sites. ACTH is also release y, anxiety response to stress (such as trauma, surg and emotional disturbance). See also: . Circadian Variation of ACTH Secretic